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CyFlow™ CD1a FITC

CyFlow™ CD1a FITC
Antigen: CD1a
Alternative Name: CD1, HTA1, R4
Clone: SK9
Application: Flow cytometry
Format/Fluorochrome: FITC
Laser: Blue
Target Species: Human
Field of Interest: Immunophenotyping
Species of Origin: Mouse
Regulatory Status: RUO
Clonality: monoclonal
Emission Maximum: 518 nm
Excitation Maximum: 490 to 495 nm
Isotype: IgG2b
Order number: CW604703

For Research Use Only
Not for use in diagnostic or therapeutic procedures.

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*1 Offer valid until 31/10/2017
HLDA Workshop HLDA II Quantity 100 tests Volume 0.4 Immunogen Human thymocytes... more
CyFlow™ CD1a FITC
HLDA WorkshopHLDA II
Quantity100 tests
Volume0.4
ImmunogenHuman thymocytes
Specifity13.06
Background InformationCD1a, together with CD1b and CD1c, belongs to group 1 of CD1 glycoproteins. These proteins serve as antigen-presenting molecules for a subset of T cells that responds to specific lipids and glycolipids found in the cell walls of bacterial pathogens or self-glycolipid antigens such as gangliosides, and they have also roles in antiviral immunity. Unlike CD1b, CD1a is excluded from late endosomal compartments and instead traffics independently in the recycling pathway of the early endocytic system, and CD1a antigen presentation is independent upon vesicular acidification.
UsageThe reagent is designed for Flow Cytometry analysis of human blood cells. Recommended usage is 4·µl reagent·/ 100·µl of whole blood or 10^6 cells in a suspension. The content of a vial (0.4 ml) is sufficient for 100 tests.
Storage BufferThe reagent is provided in stabilizing phosphate buffered saline (PBS) solution, pH ≈7.4, containing 0.09% (w/v) sodium azide.
StorageAvoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
StabilityDo not use after expiration date stamped on vial label.

Specific References

| Wood GS, Burns BF, Dorfman RF, Warnke RA: The immunohistology of non‑T cells in the acquired immunodeficiency syndrome. Am·J·Pathol. 1985·Sep; 120(3):371‑9. <·PMID:·3898858·> | Zimmer MI, Larregina AT, Castillo CM, Capuano S 3rd, Falo LD Jr, Murphey-Corb M, Reinhart TA, Barratt-Boyes SM: Disrupted homeostasis of Langerhans cells and interdigitating dendritic cells in monkeys with AIDS. Blood. 2002·Apr·15; 99(8):2859‑68. <·PMID:·11929776·> | Tenca C, Merlo A, Zarcone D, Saverino D, Bruno S, De Santanna A, Ramarli D, Fabbi M, Pesce C, Deaglio S, Ciccone E, Malavasi F, Grossi CE: Death of T cell precursors in the human thymus: a role for CD38. Int·Immunol. 2003·Sep; 15(9):1105‑16. <·PMID:·12917263·> | Brown KN, Trichel A, Barratt-Boyes SM: Parallel loss of myeloid and plasmacytoid dendritic cells from blood and lymphoid tissue in simian AIDS. J·Immunol. 2007·Jun·1; 178(11):6958‑67. <·PMID:·17513745·> | Awasthi S, Wolf R, White G: Ontogeny and phagocytic function of baboon lung dendritic cells. Immunol·Cell·Biol. 2009·Jul; 87(5):419‑27. <·PMID:·19223853·> | Kader M, Smith AP, Guiducci C, Wonderlich ER, Normolle D, Watkins SC, Barrat FJ, Barratt-Boyes SM: Blocking TLR7‑ and TLR9‑mediated IFN‑α: production by plasmacytoid dendritic cells does not diminish immune activation in early SIV infection. PLoS·Pathog. 2013; 9(7):e1003530. <·PMID:·23935491·>